Intramolecular Larock Indole Synthesis: Preparation of 3,4-Fused Tricyclic Indoles and Total Synthesis of Fargesine

被引：127

作者：

Shan, Dong ^{[1
]}

Gao, Yan ^{[1
]}

Jia, Yanxing ^{[1
,2
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 18期

基金：

中国国家自然科学基金;

关键词：

natural products; nitrogen heterocycles; palladium; synthetic methods; total synthesis; EFFICIENT TOTAL-SYNTHESIS; FORMAL TOTAL-SYNTHESIS; ACID METHYL-ESTER; NATURAL-PRODUCTS; (+)-LYSERGIC ACID; INTERNAL ALKYNES; FUSED INDOLES; CYCLIZATION; HETEROANNULATION; DIAZONAMIDE;

D O I：

10.1002/anie.201300571

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Core strength: A new and general strategy for the construction of 3,4-fused tricyclic indoles, which are the core structure of numerous natural products and bioactive molecules, has been developed. The method involves a one-step intramolecular Larock indolization and was successfully applied to the first total synthesis of fargesine. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：4902 / 4905

页数：4

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