The relationship between age-related development of spike-and-wave discharges and the resistance to amygdaloid kindling in rats with genetic absence epilepsy

被引：23

作者：

Carcak, Nihan ^{[2
]}

Aker, Rezzan Guelhan ^{[1
,3
]}

Oezdemir, Osman ^{[2
]}

Demiralp, Tamer ^{[4
]}

Onat, Filiz Yilmaz ^{[1
,3
]}

机构：

[1] Marmara Univ, Sch Med, Dept Pharmacol & Clin Pharmacol, TR-34668 Istanbul, Turkey

[2] Istanbul Univ, Dept Pharmacol, Fac Pharm, Istanbul, Turkey

[3] Marmara Univ, Epilepsy Res Ctr, EPAM, TR-34668 Istanbul, Turkey

[4] Istanbul Univ, Dept Physiol, Fac Med, Istanbul, Turkey

来源：

NEUROBIOLOGY OF DISEASE | 2008年 / 32卷 / 03期

关键词：

Temporal lobe epilepsy model; Absence epilepsy model; GAERS; Amygdaloid stimulation; Limbic seizures; Kindling resistance;

D O I：

10.1016/j.nbd.2008.07.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genetic Absence Epilepsy Rats from Strasbourg (GAERS) are resistant to amygdaloid kindling. Since in GAERS the characteristics of spike-and-wave discharges (SWDs) change with age, we have studied the relation between SWD maturation and the development of kindling resistance. Non-epileptic Wistar rats and GAERS were stimulated in basolateral amygdala with 400 mu A at 20 min intervals until they reached stage 5 seizures or for a maximum of 36 stimulations. All of the Wistar rats, the postnatal (PN) day 20 GAERS and the (kindling-prone) subgroups of GAERS at PN30 and PN60 reached stage 5 seizures; at PN20, PN30 and PN60 kindling rates were significantly slower in GAERS compared to Wistar rats. At PN30 and PN60, 41% and 69% of GAERS, respectively, showed no stage 3, 4 or 5 seizures after 36 stimulations (kindling-resistant subgroups). The SWD maturation involves changes in spectral patterns and correlate with age-related increases in kindling resistance in GAERS. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：355 / 363

页数：9

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