The stem cell compartment in human interfollicular epidermis

被引：95

作者：

Watt, FM ^{[1
]}

机构：

[1] Imperial Canc Res Fund, London WC2A 3PX, England

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 2002年 / 28卷 / 03期

关键词：

epidermal stem cells; c-Myc; beta-catenin; integrins; Notch;

D O I：

10.1016/S0923-1811(02)00003-8

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

In this review, I summarise recent work from my laboratory in which we have been examining the distribution of stem cells in human interfollicular epidermis and the factors that regulate stem cell fate in vitro. The non-random distribution of stem cells is emphasised and beta1 integrins and Deltal are suggested to play a role in stem cell patterning. beta1 integrins, Notch, c-Myc and beta-catenin all regulate the size of the stem cell compartment in vitro and recent evidence from transgenic mice suggests that they are also important in vivo. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

收藏

页码：173 / 180

页数：8

相关论文

共 36 条

[1] FIBRONECTIN INHIBITS THE TERMINAL DIFFERENTIATION OF HUMAN KERATINOCYTES [J].

ADAMS, JC ;

WATT, FM .

NATURE, 1989, 340 (6231) :307-309

[2] c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny [J].

Arnold, I ;

Watt, FM .

CURRENT BIOLOGY, 2001, 11 (08) :558-568

[3] 3 CLONAL TYPES OF KERATINOCYTE WITH DIFFERENT CAPACITIES FOR MULTIPLICATION [J].

BARRANDON, Y ;

GREEN, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (08) :2302-2306

[4] Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes [J].

Brakebusch, C ;

Grose, R ;

Quondamatteo, F ;

Ramirez, A ;

Jorcano, JL ;

Pirro, A ;

Svensson, M ;

Herken, R ;

Sasaki, T ;

Timpl, R ;

Werner, S ;

Fässler, R .

EMBO JOURNAL, 2000, 19 (15) :3990-4003

[5] Contrasting localization of c-Myc with other Myc superfamily transcription factors in the human hair follicle and during the hair growth cycle [J].

Bull, JJ ;

Müller-Röver, S ;

Patel, SV ;

Chronnell, MT ;

McKay, IA ;

Philpott, MP .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2001, 116 (04) :617-622

[6] Cultured human sole-derived keratinocyte grafts re-express site-specific differentiation after transplantation [J].

Compton, CC ;

Nadire, KB ;

Regauer, S ;

Simon, M ;

Warland, G ;

O'Connor, NE ;

Gallico, GG ;

Landry, DB .

DIFFERENTIATION, 1998, 64 (01) :45-53

[7]

Ferraris C, 2000, DEVELOPMENT, V127, P5487

[8] c-Myc promotes differentiation of human epidermal stem cells [J].

Gandarillas, A ;

Watt, FM .

GENES & DEVELOPMENT, 1997, 11 (21) :2869-2882

[9] De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in skin [J].

Gat, U ;

DasGupta, R ;

Degenstein, L ;

Fuchs, E .

CELL, 1998, 95 (05) :605-614

[10]

HALL PA, 1989, DEVELOPMENT, V106, P619

← 1 2 3 4 →