Advanced nanogel engineering for drug delivery

被引：395

作者：

Raemdonck, Koen ^{[1
]}

Demeester, Joseph ^{[1
]}

De Smedt, Stefaan ^{[1
]}

机构：

[1] Univ Ghent, GRGN, Lab Gen Biochem & Phys Pharm, B-9000 Ghent, Belgium

来源：

SOFT MATTER | 2009年 / 5卷 / 04期

关键词：

ASSEMBLED HYDROGEL NANOPARTICLES; TRANSFER RADICAL POLYMERIZATION; BIODEGRADABLE DEXTRAN NANOGELS; STIMULI-RESPONSIVE NANOGELS; CORE-SHELL NANOPARTICLES; TUMOR EXTRACELLULAR PH; PEG TETHERED CHAINS; IN-VITRO; INTRACELLULAR DELIVERY; CONTROLLED-RELEASE;

D O I：

10.1039/b811923f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Nanosized hydrogels (nanogels) have attracted considerable attention as multifunctional polymer-based drug delivery systems. Their versatility is demonstrated both in drug encapsulation and drug release. Nanogels can be designed to facilitate the encapsulation of diverse classes of bioactive compounds. With optimization of their molecular composition, size and morphology, nanogels can be tailor-made to sense and respond to environmental changes in order to ensure spatial and stimuli-controlled drug release in vivo. This manuscript aims to highlight recent advances in the interface between biology and nanomedicine with the emphasis on nanogels as carriers for controlled drug delivery.

引用

页码：707 / 715

页数：9

共 104 条

[1] Stimuli-responsive polymer gels [J].

Ahn, Suk-Kyun ;

Kasi, Rajeswari M. ;

Kim, Seong-Cheol ;

Sharma, Nitin ;

Zhou, Yuxiang .

SOFT MATTER, 2008, 4 (06) :1151-1157

[2] Self-assembled nanogels of cholesteryl-modified polysaccharides: Effect of the polysaccharide structure on their association characteristics in the dilute and semidilute regimes [J].

Akiyama, Eri ;

Morimoto, Nobuyuki ;

Kujawa, Piotr ;

Ozawa, Yayoi ;

Winnik, Francoise M. ;

Akiyoshit, Kazunari .

BIOMACROMOLECULES, 2007, 8 (08) :2366-2373

[3] SELF-AGGREGATES OF HYDROPHOBIZED POLYSACCHARIDES IN WATER - FORMATION AND CHARACTERISTICS OF NANOPARTICLES [J].

AKIYOSHI, K ;

DEGUCHI, S ;

MORIGUCHI, N ;

YAMAGUCHI, S ;

SUNAMOTO, J .

MACROMOLECULES, 1993, 26 (12) :3062-3068

[4] Self-assembled cationic nanogels for intracellular protein delivery [J].

Ayame, Hirohito ;

Morimoto, Nobuyuki ;

Akiyoshi, Kazunari .

BIOCONJUGATE CHEMISTRY, 2008, 19 (04) :882-890

[5] Synthesis, characterization, and intracellular delivery of reducible heparin nanogels for apoptotic cell death [J].

Bae, Ki Hyun ;

Mok, Hyejung ;

Park, Tae Gwan .

BIOMATERIALS, 2008, 29 (23) :3376-3383

[6] Temperature-, pH-, and magnetic-field-sensitive hybrid microgels [J].

Bhattacharya, Sanchita ;

Eckert, Franziska ;

Boyko, Volodymyr ;

Pich, Andrij .

SMALL, 2007, 3 (04) :650-657

[7] Size-controlled synthesis of monodisperse core/shell nanogels [J].

Blackburn, William H. ;

Lyon, L. Andrew .

COLLOID AND POLYMER SCIENCE, 2008, 286 (05) :563-569

[8] Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs [J].

Bontha, Satya ;

Kabanov, Alexander V. ;

Bronich, Tatiana K. .

JOURNAL OF CONTROLLED RELEASE, 2006, 114 (02) :163-174

[9] Controlled/living radical polymerization: Features, developments, and perspectives [J].

Braunecker, Wade A. ;

Matyjaszewski, Krzysztof .

PROGRESS IN POLYMER SCIENCE, 2007, 32 (01) :93-146

[10]

Brown JM, 1998, CANCER RES, V58, P1408

← 1 2 3 4 5 6 7 8 9 10 →