Inhibition of gamma interferon synthesis by catecholamines

被引:26
作者
AndradeMena, CE
机构
[1] Laboratorio de Inmunologia Centro, Univ. de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jal., C.P. 44281
关键词
gamma interferon; inhibition; epinephrine; norepinephrine;
D O I
10.1016/S0165-5728(97)00015-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In vitro incubation of Listeria monocytogenes immune spleen cells in the presence of the catecholamines epinephrine or norepinephrine inhibited the gamma interferon (IFN-gamma) synthesis induced by the mitogen PHA, in a manner that appeared to be concentration dependent. Moreover, the inhibitory effect of both catecholamines epinephrine and norepinephrine on the synthesis of IFN-gamma was prevented by incubating immune spleen cells in the presence of propranolol, a beta adrenergic antagonist agent.
引用
收藏
页码:10 / 14
页数:5
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