Dynamics of the nuclear envelope at mitosis and during apoptosis

被引:40
作者
Buendia, B
Courvalin, JC
Collas, P
机构
[1] Univ Oslo, Fac Med, Inst Med Biochem, N-0317 Oslo, Norway
[2] Univ Paris 07, Inst Jacques Monod, F-75251 Paris 05, France
关键词
nuclear envelope; lamin; chromatin; mitosis; apoptosis;
D O I
10.1007/PL00000818
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The nuclear envelope is a highly dynamic structure that reversibly disassembles and reforms at mitosis. The nuclear envelope also breaks down - irreversibly - during apoptosis, a process essential for development and tissue homeostasis. Analyses of fixed cells, time-lapse, imaging studies of live cells and the development of powerful cell-free extracts derived from gametes or mammalian somatic cells have provided insights on the fate of nuclear envelope proteins during mitosis and apoptosis, and on the mechanisms behind nuclear envelope modifications in these processes. In this review, we discuss evidence leading to our understanding of the dynamics of the nuclear envelope alterations at mitosis and during apoptosis. We also present novel imaging and genetic approaches to the study of nuclear envelope dynamics and function.
引用
收藏
页码:1781 / 1789
页数:9
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