Cutting edge:: Identification of E-cadherin as a ligand for the murine killer cell lectin-like receptor G1

被引:121
作者
Gründemann, C
Bauer, M
Schweier, O
von Oppen, N
Lässing, U
Saudan, P
Becker, KF
Karp, K
Hanke, T
Bachmann, MF
Pircher, H
机构
[1] Inst Med Microbiol & Hyg, D-79104 Freiburg, Germany
[2] Univ Freiburg, Inst Med Microbiol & Hyg, Dept Immunol, D-7800 Freiburg, Germany
[3] Cytos Biotechnol AG, Zurich, Switzerland
[4] Tech Univ Munich, Inst Pathol, D-8000 Munich, Germany
[5] Univ Wurzburg, Inst Virol & Immunobiol, D-97070 Wurzburg, Germany
关键词
D O I
10.4049/jimmunol.176.3.1311
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The killer cell lectin-like receptor G1 (KERG1) is expressed by NK cells and by T cells. In both humans and mice, KLRG1 identifies Ag-experienced T cells that are impaired in their proliferative capacity but are capable of performing effect or functions. In this study, we identified E-cadherin as a ligand for murine KLRG1 by using fluorescently labeled, soluble tetrameric complexes of the extracellular domain of the murine KLRG1 molecule as staining reagents in expression cloning. Ectopic expression of E-cadherin in B16.BL6 target cells did not affect cell-mediated lysis by lymphokine-activated NK cells and by CD8 T cells but inhibited Ag-induced proliferation and induction of cytolytic activity of CD8 T cells. E-cadherin is expressed by normal epithelial cells, Langerhans cells, and keratinocytes and is usually down-regulated on metastatic cancer cells. KLRG1 ligation by E-cadherin in healthy tissue may thus exert an inhibitory effect on primed T cells. The Journal of Immunology, 2006.
引用
收藏
页码:1311 / 1315
页数:5
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