Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer

被引：44

作者：

Adachi, Yoshihiro ^{[1
]}

Takeuchi, Tamotsu ^{[1
]}

Nagayama, Tomoko ^{[2
]}

Ohtsuki, Yuji ^{[3
]}

Furihata, Mutsuo ^{[1
]}

机构：

[1] Kochi Med Sch, Dept Pathol, Nanko Ku, Kochi 7838505, Japan

[2] JST Innovat Satellite Kochi Pract Applicat Res, Tosayamada, Japan

[3] Matsuyama Shimin Hosp, Div Pathol, Matsuyama, Ehime, Japan

来源：

FEBS LETTERS | 2009年 / 583卷 / 02期

关键词：

Gallbladder cancer; T-cadherin; Zeb1; Epithelial-mesenchymal transition; Cancer invasion; EPITHELIAL-MESENCHYMAL TRANSITION; H-CADHERIN; ABERRANT METHYLATION; NEGATIVE REGULATOR; CELL-ADHESION; P53; PROTEIN; EXPRESSION; CDH13; GENE; DELTA-EF1;

D O I：

10.1016/j.febslet.2008.12.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we report that the transcriptional regulator Zeb1 repressed the transcription of T-cadherin, to increase the invasive activity of gallbladder cancer cells. Zeb1 physically bound to the promoter of T-cadherin, repressed promoter activity in E-box-like sequence-dependent fashion, and suppressed T-cadherin expression. In gallbladder cancer tissues, Zeb1 was expressed at the cancer invasion front, whereas T-cadherin was exclusively expressed in non-invasive foci. Collagen gel invasion assay showed that T-cadherin was a negative regulator for gallbladder cancer invasion. These findings suggest that Zeb1 represses T-cadherin expression and thus increases the invasive activity of gallbladder cancer. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：430 / 436

页数：7

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