Cholesterol homeostasis: Clipping out a slippery regulator

被引：15

作者：

Osborne, TF

机构：

来源：

CURRENT BIOLOGY | 1997年 / 7卷 / 03期

关键词：

D O I：

10.1016/S0960-9822(97)70081-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SREBPs are transcriptional activators central to cholesterol homeostasis. Recent work has shown that a two step cleavage of membrane-bound SREBPs frees them to enter the nucleus. An activator of the first, sterol regulated proteolysis step has also been identified.

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页码：R172 / R174

页数：3

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