Personalizing immunotherapy Balancing predictability and precision

被引：12

作者：

Agur, Zvia ^{[1
]}

Vuk-Pavlovic, Stanimir ^{[2
]}

机构：

[1] Inst Med BioMath, Bene Ataroth, Israel

[2] Mayo Clin, Coll Med, Rochester, MN USA

来源：

ONCOIMMUNOLOGY | 2012年 / 1卷 / 07期

关键词：

mathematical model; in-treatment; personalization; prostate cancer; clinical trial; CANCER;

D O I：

10.4161/onci.20955

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Despite great expectations and research efforts, anticancer immunotherapy has not yet become a definitive cure. Perhaps, this is because past reductionist approaches were too simplistic for the patient-specific complex system of co-evolving tumor cells and host immunity. Recent efforts based on a systems-based approach promise improved clinical outcomes engendered by a dynamic modification of personalized therapeutic regimens.

引用

收藏

页码：1169 / 1171

页数：3

相关论文

共 9 条

[1]

Mathematical Modeling in Immunotherapy of Cancer: Personalizing Clinical Trials [J].

Agur, Zvia ;

Vuk-Pavlovic, Stanimir .

MOLECULAR THERAPY, 2012, 20 (01) :1-2

[2]

Neoplastic "Black Ops": Cancer's subversive tactics in overcoming host defenses [J].

Biragyn, Arya ;

Longo, Dan L. .

SEMINARS IN CANCER BIOLOGY, 2012, 22 (01) :50-59

[3]

A validated mathematical model of cell-mediated immune response to tumor growth [J].

de Pillis, LG ;

Radunskaya, AE ;

Wiseman, CL .

CANCER RESEARCH, 2005, 65 (17) :7950-7958

[4]

An Integrated Disease/Pharmacokinetic/Pharmacodynamic Model Suggests Improved Interleukin-21 Regimens Validated Prospectively for Mouse Solid Cancers [J].

Elishmereni, Moran ;

Kheifetz, Yuri ;

Sondergaard, Henrik ;

Overgaard, Rune Viig ;

Agur, Zvia .

PLOS COMPUTATIONAL BIOLOGY, 2011, 7 (09)

[5]

Dendritic cell immunotherapy: mapping the way [J].

Figdor, CG ;

de Vries, IJM ;

Lesterhuis, WJ ;

Melief, CJM .

NATURE MEDICINE, 2004, 10 (05) :475-480

[6]

A methodological framework to enhance the clinical success of cancer immunotherapy [J].

Hoos, Axel ;

Britten, Cedrik M. ;

Huber, Christoph ;

O'Donnell-Tormey, Jill .

NATURE BIOTECHNOLOGY, 2011, 29 (10) :867-870

[7]

Reconsidering the Paradigm of Cancer Immunotherapy by Computationally Aided Real-time Personalization [J].

Kogan, Yuri ;

Halevi-Tobias, Karin ;

Elishmereni, Moran ;

Vuk-Pavlovic, Stanimir ;

Agur, Zvia .

CANCER RESEARCH, 2012, 72 (09) :2218-2227

[8]

Predicting Outcomes of Prostate Cancer Immunotherapy by Personalized Mathematical Models [J].

Kronik, Natalie ;

Kogan, Yuri ;

Elishmereni, Moran ;

Halevi-Tobias, Karin ;

Vuk-Pavlovic, Stanimir ;

Agur, Zvia .

PLOS ONE, 2010, 5 (12)

[9]

Delayed disease progression after allogeneic cell vaccination in hormone-resistant prostate cancer and correlation with immunologic variables [J].

Michael, A ;

Ball, G ;

Quatan, N ;

Wushishi, F ;

Russell, N ;

Whelan, J ;

Chakraborty, P ;

Leader, D ;

Whelan, M ;

Pandha, H .

CLINICAL CANCER RESEARCH, 2005, 11 (12) :4469-4478