Synthesis of syndecan-1 by skeletal muscle cells is an early response to infection with Trichinella spiralis but is not essential for nurse cell development

被引：11

作者：

Beiting, DP ^{[1
]}

Park, PW

Appleton, JA

机构：

[1] Cornell Univ, Coll Vet Med, James A Baker Inst Anim Hlth, Ithaca, NY 14853 USA

[2] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

INFECTION AND IMMUNITY | 2006年 / 74卷 / 03期

关键词：

D O I：

10.1128/IAI.74.3.1941-1943.2006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Trichinella spiralis creates a unique intracellular habitat in striated muscle. We report that a proteoglycan, syndecan-1, is induced early in infection yet is not essential for habitat development and exerts a modest influence on the immune response. This report is the first to address the requirement for a specific muscle protein in trichinellosis by using mice deficient in the relevant gene.

引用

页码：1941 / 1943

页数：3

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