Neural correlates of heart rate variability during emotion

被引:496
作者
Lane, Richard D. [1 ,2 ]
McRae, Kateri [1 ,4 ]
Reiman, Eric M. [1 ,5 ,6 ,7 ]
Chen, Kewei [5 ,6 ]
Ahern, Geoffrey L. [1 ,2 ,3 ]
Thayer, Julian F. [8 ,9 ]
机构
[1] Univ Arizona, Dept Psychiat, Tucson, AZ USA
[2] Univ Arizona, Dept Psychol, Tucson, AZ 85721 USA
[3] Univ Arizona, Dept Neurol, Tucson, AZ USA
[4] Stanford Univ, Dept Psychol, Palo Alto, CA 94304 USA
[5] Banner Good Samaritan Med Ctr, Banner Positron Emiss Tomog Ctr, Phoenix, AZ USA
[6] Banner Alzheimers Inst, Phoenix, AZ USA
[7] Translat Genom Res Inst, Phoenix, AZ USA
[8] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA
[9] Heidelberg Univ, Mannheim Inst Publ Hlth, Heidelberg, Germany
关键词
PREFRONTAL CORTEX; ANTERIOR CINGULATE; WORKING-MEMORY; INHIBITION; ACTIVATION; ATTENTION; NETWORKS; FEELINGS; METAANALYSIS; FREQUENCY;
D O I
10.1016/j.neuroimage.2008.07.056
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
The vagal (high frequency [HF]) component of heart rate variability (HRV) predicts survival in post-myocardial infarction patients and is considered to reflect vagal antagonism of sympathetic influences. Previous studies of the neural correlates of vagal tone involved mental stress tasks that included cognitive and emotional elements. To differentiate the neural substrates of vagal tone due to emotion, we correlated HF-HRV with measures of regional cerebral blood flow (rCBF) derived from positron emission tomography (PET) and O-15-water in 12 healthy women during different emotional states. Happiness, sadness, disgust and three neutral conditions were each induced by film clips and recall of personal experiences (12 conditions). Inter-beat intervals derived from electrocardiographic recordings during the 60-second scans were spectrally-analyzed, generating 12 separate measures of HF-HRV in each subject. The six emotion and six neutral conditions were grouped together and contrasted. We observed substantial overlap between emotion-specific rCBF and the correlation between emotion-specific rCBF and HF-HRV, particularly in the medial prefrontal cortex. Emotion-specific rCBF also correlated with HF-HRV in the caudate nucleus, periacqueductal gray and left mid-insula. We also observed that the elements of cognitive control inherent in this experiment (that involved focusing on the target mental state) had definable neural substrates that correlated with HF-HRV and to a large extent differed from the emotion-specific correlates of HF-HRV. No statistically significant asymmetries were observed. Our findings are consistent with the view that the medial visceromotor network is a final common pathway by which emotional and cognitive functions recruit autonomic support. (C) 2008 Published by Elsevier Inc.
引用
收藏
页码:213 / 222
页数:10
相关论文
共 72 条
[1]
Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test [J].
Ahern, GL ;
Sollers, JJ ;
Lane, RD ;
Labiner, DM ;
Herring, AM ;
Weinand, ME ;
Hutzler, R ;
Thayer, JF .
EPILEPSIA, 2001, 42 (07) :912-921
[2]
PARALLEL ORGANIZATION OF FUNCTIONALLY SEGREGATED CIRCUITS LINKING BASAL GANGLIA AND CORTEX [J].
ALEXANDER, GE ;
DELONG, MR ;
STRICK, PL .
ANNUAL REVIEW OF NEUROSCIENCE, 1986, 9 :357-381
[3]
Meeting of minds: the medial frontal cortex and social cognition [J].
Amodio, DM ;
Frith, CD .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (04) :268-277
[4]
[Anonymous], 1999, AM BIOL TEACH
[5]
[Anonymous], 1981, Cardiovascular psychophysiology, cardiovascular psychophysiology, DOI DOI 10.4324/9781315081762
[6]
[Anonymous], 1986, EMOTIONS
[7]
Heart rate variability as an index of regulated emotional responding [J].
Appelhans, Bradley M. ;
Luecken, Linda J. .
REVIEW OF GENERAL PSYCHOLOGY, 2006, 10 (03) :229-240
[8]
Inhibition and the right inferior frontal cortex [J].
Aron, AR ;
Robbins, TW ;
Poldrack, RA .
TRENDS IN COGNITIVE SCIENCES, 2004, 8 (04) :170-177
[9]
Cognitive and emotional influences in anterior cingulate cortex [J].
Bush, G ;
Luu, P ;
Posner, MI .
TRENDS IN COGNITIVE SCIENCES, 2000, 4 (06) :215-222
[10]
Camm AJ, 1996, CIRCULATION, V93, P1043