μ3 opiate receptor expression in lung and lung carcinoma:: ligand binding and coupling to nitric oxide release

被引：31

作者：

Fimiani, C

Arcuri, E

Santoni, A

Rialas, CM

Bilfinger, TV

Peter, D

Salzet, B

Stefano, GB ^{[1
]}

机构：

[1] SUNY Coll Old Westbury, Neurosci Res Inst, Old Westbury, NY 11568 USA

[2] Univ Roma La Sapienza, Dept Expt Med, Lab Cellular & Nat Immun, I-00185 Rome, Italy

[3] Regina Elena Inst Canc Res, Intens Care Unit & Pain Therapy, I-00161 Rome, Italy

[4] SUNY Stony Brook, Hlth Sci Ctr, Dept Surg, Div Cardiothorac Surg, Stony Brook, NY 11794 USA

[5] Univ Sci & Tech Lille Flandres Artois, Lab Neuroimmun Annelides, Ctr Biol Cellulaire, F-59655 Villeneuve Dascq, France

来源：

CANCER LETTERS | 1999年 / 146卷 / 01期

关键词：

opioid receptor transcript; mu neoplasia; nitric oxide; morphine; cancer; alternative splicing; lung;

D O I：

10.1016/S0304-3835(99)00227-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The mu 3 opiate receptor subtype is expressed in human surgical specimens of both normal lung and non-small-cell lung carcinoma. Nitric oxide (NO) release is mediated through the mu 3 receptor, and in lung carcinoma, morphine-stimulated NO release is significantly higher and prolonged than in normal lung. Using reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis we show that specific mu opioid receptor transcripts are present in lung carcinoma and other cells with the mu 3 profile. Our findings identify a unique role for the mu 3 opiate receptor in opiate-mediated NO release and suggest that endogenous opiates, through their release of NO, may play a role in cancer progression. (C) 1999 Elsevier Science ireland Ltd. All rights reserved.

引用

页码：45 / 51

页数：7

共 27 条

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ANTITUMOR-ACTIVITY OF NALTREXONE AND CORRELATION WITH STEROID-HORMONE RECEPTORS [J].