Immunomodulating potential of supplementation with probiotics:: a dose-response study in healthy young adults

被引:52
作者
Christensen, Hanne Risager
Larsen, Charlotte Nexmann
Kaestel, Pernille
Rosholm, Lisbeth Buus
Sternberg, Claus
Michaelsen, Kim Fleischer
Frokiaer, Hanne
机构
[1] Tech Univ Denmark, Bioctr, Biochem & Nutr Grp, DK-2800 Lyngby, Denmark
[2] Chr Hansen AS, Horsholm, Denmark
[3] Royal Vet & Agr Univ, Ctr Adv Food Studies, Dept Human Nutr, Frederiksberg, Denmark
[4] Tech Univ Denmark, Ctr Microbiol, Bioctr, Mol Microbial Ecol Grp, DK-2800 Lyngby, Denmark
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2006年 / 47卷 / 03期
关键词
probiotic; immunomodulation; healthy human adults; dose-response;
D O I
10.1111/j.1574-695X.2006.00109.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Certain probiotic microorganisms have been found beneficial in the treatment of immune-related diseases and may also affect immune function in healthy people. Intervention studies of probiotics in healthy humans are urgently required. Here, the immunomodulating potential of Bifidobacterium animalis ssp. lactis (BB-12) and Lactobacillus paracasei ssp. paracasei (CRL-431) was studied in a double-blind placebo-controlled parallel dose-response trial (n=71) based on five randomly assigned groups of young healthy adults supplemented for 3 weeks with 0, 10(8), 10(9), 10(10) and 10(11) CFU day(-1), respectively, of a mixture of BB-12 and CRL-431. No statistically significant dose-dependent effect was found for phagocytic activity in blood leukocytes, fecal immunoglobulin A (IgA) concentrations or production of interferon-gamma and interleukin-10 in blood cells. When evaluating data according to the amount of viable BB-12 recovered from faeces, the interferon-gamma production in blood cells was significantly reduced. In conclusion, no solid effect on the immune function of young healthy adults supplemented with even high doses of B. animalis ssp. lactis BB-12 and L. paracasei ssp. paracasei CRL-431 was demonstrated in this study.
引用
收藏
页码:380 / 390
页数:11
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