Deregulated EGFR Signaling during Lung Cancer Progression: Mutations, Amplicons, and Autocrine Loops

被引：73

作者：

Gazdar, Adi F. ^{[1
]}

Minna, John D.

机构：

[1] Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA

来源：

CANCER PREVENTION RESEARCH | 2008年 / 1卷 / 03期

关键词：

D O I：

10.1158/1940-6207.CAPR-08-0080

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：156 / 160

页数：5

共 37 条

[1] The new World Health Organization classification of lung tumours [J].

Brambilla, E ;

Travis, WD ;

Colby, TV ;

Corrin, B ;

Shimosato, Y .

EUROPEAN RESPIRATORY JOURNAL, 2001, 18 (06) :1059-1068

[2] Increased HER2 gene copy number is associated with response to gefitinib therapy in epidermal growth factor receptor-positive non-small-cell lung cancer patients [J].

Cappuzzo, F ;

Varella-Garcia, M ;

Shigematsu, H ;

Domenichini, I ;

Bartolini, S ;

Ceresoli, GL ;

Rossi, E ;

Ludovini, V ;

Gregorc, V ;

Toschi, L ;

Franklin, WA ;

Crino, L ;

Gazdar, AF ;

Bunn, RA ;

Hirsch, FR .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (22) :5007-5018

[3] EGF-ERBB signalling: towards the systems level [J].

Citri, Ami ;

Yarden, Yosef .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2006, 7 (07) :505-516

[4] Protein kinases - the major drug targets of the twenty-first century? [J].

Cohen, P .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (04) :309-315

[5] The role of the ErbB family members in non-small cell lung cancers sensitive to epidermal growth factor receptor kinase inhibitors [J].

Engelman, Jeffrey A. ;

Cantley, Lewis C. .

CLINICAL CANCER RESEARCH, 2006, 12 (14) :4372S-4376S

[6]

Frederick L, 2000, NEURO-ONCOLOGY, V2, P159, DOI 10.1093/neuonc/2.3.159

[7] High expression of ErbB family members and their ligands in lung adenocarcinomas that are sensitive to inhibition of epidermal growth factor receptor [J].

Fujimoto, N ;

Wislez, M ;

Zhang, J ;

Iwanaga, K ;

Dackor, J ;

Hanna, AE ;

Kalyankrishna, S ;

Cody, DD ;

Price, RE ;

Sato, M ;

Shay, JW ;

Minna, JD ;

Peyton, M ;

Tang, XM ;

Massarelli, E ;

Herbst, R ;

Threadgill, DW ;

Wistuba, II ;

Kurie, JM .

CANCER RESEARCH, 2005, 65 (24) :11478-11485

[8] Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas [J].

Gao, Sizhi Paul ;

Mark, Kevin G. ;

Leslie, Kenneth ;

Pao, William ;

Motoi, Noriko ;

Gerald, William L. ;

Travis, William D. ;

Bornmann, William ;

Veach, Darren ;

Clarkson, Bayard ;

Bromberg, Jacqueline F. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (12) :3846-3856

[9] Mutations and addiction to EGFR:: the Achilles 'heal' of lung cancers? [J].

Gazdar, AF ;

Shigematsu, H ;

Herz, J ;

Minna, JD .

TRENDS IN MOLECULAR MEDICINE, 2004, 10 (10) :481-486

[10] Targeting ADAMS and ERBBs in lung cancer [J].

Hynes, Nancy E. ;

Schlange, Thomas .

CANCER CELL, 2006, 10 (01) :7-11

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