Procalcitonin and neopterin levels do not accurately distinguish bacterial from viral infections in ill-returned travellers with fever

被引：8

作者：

Witt, Rene Te ^{[1
]}

Hassing, Robert-Jan ^{[2
]}

Petit, Pieter P. ^{[3
]}

van Belkum, Alex ^{[1
,4
]}

van Genderen, Perry J. ^{[5
,6
]}

机构：

[1] Erasmus MC, Dept Med Microbiol & Infect Dis, NL-3015 CE Rotterdam, Netherlands

[2] Erasmus MC, Dept Internal Med & Infect Dis, NL-3015 CE Rotterdam, Netherlands

[3] Vlietland Hosp, Dept Med Microbiol, NL-3118 JH Schiedam, Netherlands

[4] BioMerieux, Microbiol Res Unit, F-38390 La Balme Les Grottes, France

[5] Harbour Hosp, Dept Internal Med, NL-3011 TD Rotterdam, Netherlands

[6] Inst Trop Dis, NL-3011 TD Rotterdam, Netherlands

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2012年 / 106卷 / 04期

关键词：

Procalcitonin; Neopterin; Travellers; CRP; Leukocyte differential counts; C-REACTIVE PROTEIN; SERUM PROCALCITONIN; MARKERS;

D O I：

10.1016/j.trstmh.2012.01.001

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

100235 [预防医学];

摘要：

The diagnostic performance of procalcitonin and neopterin as markers for bacterial and viral causes of fever was evaluated in a cohort of 69 febrile travellers with known etiological agents. Our aim was to establish a decision rule to minimize empirical antibiotic treatment. Compared with C-reactive protein (CRP) and leukocyte (differential) counts, procalcitonin and neopterin had a disappointing diagnostic accuracy. Refraining from antibiotics in case of combined presence of lymphocytosis and/or CRP <= 10 mg/l would result in an 85% reduction in unwanted antibiotic treatment in patients with viral disease but in adequate antibiotic coverage of all patients with bacterial disease. (C) 2012 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：264 / 266

页数：3

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