Enzyme-activated targeting of liposomes

被引：117

作者：

Meers, P ^{[1
]}

机构：

[1] Elan Pharmaceut Technol, Princeton, NJ 08540 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 53卷 / 03期

关键词：

membrane; fusion; triggered; elastase; cancer; inflammation;

D O I：

10.1016/S0169-409X(01)00205-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

It has become increasingly evident that tissues utilize specific localization of enzymes to perform certain tasks, often associated with various types of tissue remodeling. The ubiquitous presence of such enzymes, along with their specific localizations, provides an ideal opportunity to elicit specific delivery via an enzyme-triggered mechanism. A survey of some of the recent progress in enzyme-activated targeting of delivery systems, with a focus on a few liposomal systems, is presented. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：265 / 272

页数：8

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