Activity-dependent regulation of inhibitory synapse development by Npas4

被引：459

作者：

Lin, Yingxi ^{[1
,2
,3
]}

Bloodgood, Brenda L. ^{[1
,2
,3
]}

Hauser, Jessica L. ^{[1
,2
,3
]}

Lapan, Ariya D. ^{[4
]}

Koon, Alex C. ^{[1
,2
,3
]}

Kim, Tae-Kyung ^{[1
,2
,3
]}

Hu, Linda S. ^{[1
,2
,3
]}

Malik, Athar N. ^{[1
,2
,3
,5
]}

Greenberg, Michael E. ^{[1
,2
,3
]}

机构：

[1] Harvard Univ, Sch Med, FM Kirby Neurobiol Ctr, Childrens Hosp, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[4] Harvard Univ, Sch Med, Program Biol & Biomed Sci, Boston, MA 02115 USA

[5] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

来源：

NATURE | 2008年 / 455卷 / 7217期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1038/nature07319

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neuronal activity regulates the development and maturation of excitatory and inhibitory synapses in the mammalian brain. Several recent studies have identified signalling networks within neurons that control excitatory synapse development. However, less is known about the molecular mechanisms that regulate the activity- dependent development of GABA (gamma-aminobutyric acid)- releasing inhibitory synapses. Here we report the identification of a transcription factor, Npas4, that plays a role in the development of inhibitory synapses by regulating the expression of activity- dependent genes, which in turn control the number of GABA- releasing synapses that form on excitatory neurons. These findings demonstrate that the activity- dependent gene program regulates inhibitory synapse development, and suggest a new role for this program in controlling the homeostatic balance between synaptic excitation and inhibition.

引用

页码：1198 / U23

页数：8

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