Benzastatins E, F, and G: New indoline alkaloids with neuronal cell protecting activity from Streptomyces nitrosporeus

被引：48

作者：

Kim, WG

Kim, JP

Koshino, H

ShinYa, K

Seto, H

Yoo, ID

机构：

[1] KIST,KOREA RES INST BIOSCI & BIOTECHNOL,TAEJON 305600,SOUTH KOREA

[2] RIKEN,INST PHYS & CHEM RES,WAKO,SAITAMA 35101,JAPAN

[3] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON | 1997年 / 53卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(97)00157-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new indoline alkaloids, benzastatins E (5), F (6), and G (7), were isolated from the culture broth of Streptomyces nitrosporeus 30643 as neuronal cell protecting substances. Their structures were elucidated on the basis of spectral data. 5, 6, and 7 suppressed glutamate toxicity in N18-RE-105 cells with ECS, values of 1.7, 3.6, and 12.2 mu M, respectively. (C) 1997 Elsevier Science Ltd.

引用

页码：4309 / 4316

页数：8

共 18 条

[1]

[Anonymous], 1995, DICT NATURAL PRODUCT

[2]

CHOI DW, 1990, J NEUROSCI, V10, P2493

[3] OXIDATIVE STRESS, GLUTAMATE, AND NEURODEGENERATIVE DISORDERS [J].