Benzastatins E, F, and G: New indoline alkaloids with neuronal cell protecting activity from Streptomyces nitrosporeus

被引:48
作者
Kim, WG
Kim, JP
Koshino, H
ShinYa, K
Seto, H
Yoo, ID
机构
[1] KIST,KOREA RES INST BIOSCI & BIOTECHNOL,TAEJON 305600,SOUTH KOREA
[2] RIKEN,INST PHYS & CHEM RES,WAKO,SAITAMA 35101,JAPAN
[3] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN
关键词
D O I
10.1016/S0040-4020(97)00157-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Three new indoline alkaloids, benzastatins E (5), F (6), and G (7), were isolated from the culture broth of Streptomyces nitrosporeus 30643 as neuronal cell protecting substances. Their structures were elucidated on the basis of spectral data. 5, 6, and 7 suppressed glutamate toxicity in N18-RE-105 cells with ECS, values of 1.7, 3.6, and 12.2 mu M, respectively. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:4309 / 4316
页数:8
相关论文
共 18 条
[1]  
[Anonymous], 1995, DICT NATURAL PRODUCT
[2]  
CHOI DW, 1990, J NEUROSCI, V10, P2493
[3]   OXIDATIVE STRESS, GLUTAMATE, AND NEURODEGENERATIVE DISORDERS [J].
COYLE, JT ;
PUTTFARCKEN, P .
SCIENCE, 1993, 262 (5134) :689-695
[4]   PULSED-FIELD GRADIENT ONE-DIMENSIONAL NMR SELECTIVE ROE AND TOCSY EXPERIMENTS [J].
DALVIT, C ;
BOVERMANN, G .
MAGNETIC RESONANCE IN CHEMISTRY, 1995, 33 (02) :156-159
[5]   GRADIENT-ENHANCED PROTON-DETECTED HETERONUCLEAR MULTIPLE-QUANTUM COHERENCE SPECTROSCOPY [J].
HURD, RE ;
JOHN, BK .
JOURNAL OF MAGNETIC RESONANCE, 1991, 91 (03) :648-653
[6]   2-(AMINOMETHYL)CHROMANS THAT INHIBIT IRON-DEPENDENT LIPID-PEROXIDATION AND PROTECT AGAINST CENTRAL-NERVOUS-SYSTEM TRAUMA AND ISCHEMIA [J].
JACOBSEN, EJ ;
VANDOORNIK, FJ ;
AYER, DE ;
BELONGA, KL ;
BRAUGHLER, JM ;
HALL, ED ;
HOUSER, DJ .
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (23) :4464-4472
[7]   Benzastatins A, B, C, and D: New free radical scavengers from Streptomyces nitrosporeus 30643 .2. Structure determination [J].
Kim, WG ;
Kim, JP ;
Yoo, ID .
JOURNAL OF ANTIBIOTICS, 1996, 49 (01) :26-30
[8]  
KIM WG, 1996, ANTIBIOTICS, V49, P20
[9]   ATTENUATION OF FOCAL CEREBRAL ISCHEMIC-INJURY IN TRANSGENIC MICE OVEREXPRESSING CUZN SUPEROXIDE-DISMUTASE [J].
KINOUCHI, H ;
EPSTEIN, CJ ;
MIZUI, T ;
CARLSON, E ;
CHEN, SF ;
CHAN, PH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11158-11162
[10]  
MALOUF AT, 1984, J BIOL CHEM, V20, P12756