Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis

被引：182

作者：

Beattie, J ^{[1
]}

Allan, GJ ^{[1
]}

Lochrie, JD ^{[1
]}

Flint, DJ ^{[1
]}

机构：

[1] Hannah Res Inst, Ayr KA6 5HL, Scotland

来源：

BIOCHEMICAL JOURNAL | 2006年 / 395卷

关键词：

extracellular matrix (ECM); glycosaminoglycan; insulin-like growth factor-I (IGF-I); insulin-like growth factor-binding protein 5 (IGFBP-5); mammary gland; proteolysis;

D O I：

10.1042/BJ20060086

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The six members of the insulin-like growth factor-binding protein family (IGFBP-1-6) are important components of the IGF (insulin-like growth factor) axis. In this capacity, they serve to regulate the activity of both IGF-I and -II polypeptide growth factors. The IGFBPs are able to enhance or inhibit the activity of IGFs in a cell- and tissue-specific manner. One of these proteins, IGFBP-5, also has an important role in controlling cell survival, differentiation and apoptosis. In this review, we report on the structural and functional features of the protein which are important for these effects. We also examine the regulation of IGFBP-5 expression and comment on its potential role in tumour biology, with special reference to work with breast cancer cells.

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页码：1 / 19

页数：19

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