Effect of intravenous pamidronate therapy on functional abilities and level of ambulation in children with osteogenesis imperfecta

Objective To evaluate the functional abilities and the level of ambulation during painidronate therapy in children with moderate to severe osteogenesis imperfecta. Study design Functional abilities, ambulation, and grip force were assessed in 59 patients (mean age, 6.1 years; range, 0.5-15.7 years; 30 girls) during 3 years of pamidronate treatment. Functional skulls (mobility and self-care) were both assessed by using the Pediatric Evaluation of Disability Inventory. Ambuladon level was assessed by using the modified Bleck score. For 48 patients, results after 3 years of pamidronate treatment could be matched to those of patients with similar age and disease severity who had not received pamidronate. Results Mobility and self-care scores increased during the study period (+43% and +30%, respectively). The average\ ambulation score changed from 0.8 to 1.9. Maximal isometric grip force increased by 63%. Mobility and ambulation scores and grip force measures were significantly higher than in patients who had not received painidronate. The difference in self-care scores did not reach significance. Conclusion Thus study suggests that cyclical painidronate treatment improves mobility, ambulation level. and muscle force in children with moderate to severe osteogenesis imperfecta.