Synthesis and cytotoxicity of 3,4-diaryl-2(5H)-furanones

被引:91
作者
Kim, Y [1 ]
Nam, NH [1 ]
You, YJ [1 ]
Ahn, BZ [1 ]
机构
[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea
关键词
D O I
10.1016/S0960-894X(01)00831-9
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of 3,4-diaryl-2(5H)-furanone derivatives were synthesized and evaluated for their cytotoxicity in a small panel of cancer cell lines. Four out of 10 compounds in this series, for example 3-(3,4,5-trimethoxyphenyl)-4-(4-methoxyphenyl)-, 3-(3,4,5-trimethoxyphenyl)-4-(3-hydroxy-4-methoxyphenyl)-, 3- (3,4,5-trimethoxyphenyl)-4-(3-amino-4-methoxyphenyl)-, and 3-(3,4,5-trimethoxyphenyl) -4- (2-naphthyl)-2(5H)-furanones, were found to have potent cytotoxic activities with ED50 values of less than 20 nM in most of the cell lines tested. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:719 / 722
页数:4
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