Glyceroglycolipids, a novel class of platelet-activating factor antagonists from Kalimeris indica

被引：21

作者：

Fan, Gao-jun ^{[1
]}

Kim, Sanghee ^{[1
]}

Han, Byung Hoon ^{[1
]}

Han, Yong Nam ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 151742, South Korea

来源：

PHYTOCHEMISTRY LETTERS | 2008年 / 1卷 / 04期

关键词：

Kalimeris indica; Astercaceae; Platelet-activating factor (PAF); Receptor binding inhibitor; Glyceroglycolipid;

D O I：

10.1016/j.phytol.2008.09.011

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The bioassay-guided purification of chloroform extracts of Kalimeris indica (Linn) Schultz-Bip led to the isolation of three diacylglycerols: 1-O-(9Z, 12Z, 15Z-octadecatrienoyl)-2-O-hexadecanoylglycerol (1), 1-O-(9Z, 12Z, 15Z-octadecatrienoyl)-2-O-hexadecanoyl-3-O-alpha-(6-sulfoquinovopyranosyl)glycerol (2), 1-O-(9Z, 12Z, 15Z-octadecatrienoyl)-2-O-hexadecanoyl-3-O-[alpha-D-galactopyranosyl (1 -> 6)-O-beta-D-galactopyranosyl]glycerol (3). Their structures were established on the basis of spectral and chemical methods. The glyceroglycolipids 2 and 3 exhibited significant PAIF receptor binding inhibitory activities. Our studies have identified diacylglycolipids as a novel class of potent PAF antagonist. (C) 2008 Phytochemical Society of Europe Published by Elsevier B.V. All rights reserved.

引用

页码：207 / 210

页数：4

共 21 条

[1]

BRAQUET P, 1987, PHARMACOL REV, V39, P97

[2]

Braquet P, 1985, BLOOD VESSELS, V16, P558, DOI DOI 10.2491/jjsth1970.16.558

[3]

C-13-NMR ANALYSIS OF THE POSITIONAL DISTRIBUTION OF FATTY-ACIDS IN PLANT GLYCOLIPIDS [J].

DIEHL, BWK ;

HERLING, H ;

RIEDL, I ;

HEINZ, E .

CHEMISTRY AND PHYSICS OF LIPIDS, 1995, 77 (02) :147-153

[4]

Fan GaoJun, 2001, Natural Product Sciences, V7, P33

[5]

AIDS-ANTIVIRAL SULFOLIPIDS FROM CYANOBACTERIA (BLUE-GREEN-ALGAE) [J].

GUSTAFSON, KR ;

CARDELLINA, JH ;

FULLER, RW ;

WEISLOW, OS ;

KISER, RF ;

SNADER, KM ;

PATTERSON, GML ;

BOYD, MR .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (16) :1254-1258

[6]

IWAKAMI S, 1992, CHEM PHARM BULL, V40, P1196, DOI 10.1248/cpb.40.1196

[7]

*JIANGS NEW MED I, 1978, DICT CHIN MED, P280

[8]

STUDIES ON CHLOROPLAST MEMBRANES .3. C-13 CHEMICAL-SHIFTS AND LONGITUDINAL RELAXATION-TIMES OF 1,2-DIACYL-3-(6-SULPHO-ALPHA-QUINOVOSYL)-SN-GLYCEROL [J].

JOHNS, SR ;

LESLIE, DR ;

WILLING, RI ;

BISHOP, DG .

AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (01) :65-72

[9]

Diacylglycerylgalactosides from Arisaema amurense [J].

Jung, JH ;

Lee, H ;

Kang, SS .

PHYTOCHEMISTRY, 1996, 42 (02) :447-452

[10]

LIN C, 2006, ZHONGGUO YAOXUE ZAZH, V41, P251

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