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Practical synthesis of indolopyrrolocarbazoles

被引：120
作者：
Ohkubo, M
Nishimura, T
Jona, H
Honma, T
Morishima, H
机构：
[1] Banyu Tukuba Research Institute, Merck Research Laboratories, Tsukuba 300-33
来源：
TETRAHEDRON | 1996年 / 52卷 / 24期
关键词：
D O I：
10.1016/0040-4020(96)00372-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A practical method for the synthesis of an indolo[2,3-a]pyrrolo[3,4-c]carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (It) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7). Copyright (C) 1996 Elsevier Science Ltd
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页码：8099 / 8112
页数：14
相关论文
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