Novel quinazolone derivatives as antitumor agents

A novel series of quinazolones bearing 2-benzoylmethylthio 3, 2-benzoylmethylsulfonyl 4, 1,3,4-oxadiazine 6, 1,2,4-triazine 7, ethyl ester 8, pyrazolidine-3,5-dione 9, semicarbazide 10, 1,2,4,5-tetrazine-3-one 11, pyridazine-3,5-dione 12, 13, hydrazonoacetic acid 14, pyridazine-3,6-dione 16, pyrazole 17, 1,2,4-triazine-5-one 18, triazole 19 and thiosemicarbazide 20 have been synthesized. Their structures have been confirmed on the basis of elemental analyses and (IR, H-1-NMR & Mass) spectral data. Preliminary testing for the in vitro antitumor activity of compounds 1, 3, 4, and 15-20 against Ehrlich Ascites Carcinoma cells was carried out. The most active compounds are those of chloroacetylhydrazine derivative 15, pyridazine derivative 16, sulfonyl derivative 4, and triazine derivative 18, respectively.