Focal adhesion assembly

被引：198

作者：

Burridge, K ^{[1
]}

ChrzanowskaWodnicka, M ^{[1
]}

Zhong, CL ^{[1
]}

机构：

[1] UNIV N CAROLINA,LINEBERGER COMPREHENS CANC CTR,CHAPEL HILL,NC 27599

来源：

TRENDS IN CELL BIOLOGY | 1997年 / 7卷 / 09期

关键词：

D O I：

10.1016/S0962-8924(97)01127-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The GTP-binding protein Rho regulates the assembly of focal adhesions and their associated bundles of actin filaments. Two different lines of research have converged to reveal how Rho might regulate assembly of these structures. One approach has been the identification of downstream effectors of Rho, whereas the other has been the exploration of the role of contractility ist promoting assembly. It is now apparent that Rho is a key regulator of actomyosin-based contractility in nonmuscle cells and that contractility, combined with adhesion to a rigid substrate, leans to the formation of both stress fibres and focal adhesions.

引用

页码：342 / 347

页数：6

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