Discovery, Synthesis, and Structure Activity Relationships of Conotoxins

被引：268

作者：

Akondi, Kalyana B. ^{[1
]}

Muttenthaler, Markus ^{[2
,3
]}

Dutertre, Sebastien ^{[4
]}

Kaas, Quentin ^{[1
]}

Craik, David J. ^{[1
]}

Lewis, Richard J. ^{[1
]}

Alewood, Paul F. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

[2] Inst Res Biomed, Dept Chem, Barcelona 08028, Spain

[3] Inst Res Biomed, Dept Mol Pharmacol, Barcelona 08028, Spain

[4] Univ Montpellier 2, CNRS, Inst Biomol Max Mousseron, UMR 5247, F-34095 Montpellier 5, France

来源：

CHEMICAL REVIEWS | 2014年 / 114卷 / 11期

基金：

澳大利亚国家健康与医学研究理事会; 澳大利亚研究理事会; 英国医学研究理事会;

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTOR; PHASE PEPTIDE-SYNTHESIS; NUCLEAR-MAGNETIC-RESONANCE; GAMMA-CARBOXYGLUTAMIC ACID; RESISTANT SODIUM-CHANNELS; VITRO BIOLOGICAL-ACTIVITY; TOTAL CHEMICAL-SYNTHESIS; CYSTEINE-RICH PEPTIDES; DISULFIDE BOND ISOMERS; X-RAY-STRUCTURE;

D O I：

10.1021/cr400401e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena, and they continue to attract interest due to their high potency, bioavailability, and fewer concerns with toxicity, drug to drug cross-reactions, and tissue accumulation. Around 700 species of marine snails of the genus Conus are distributed throughout tropical and subtropical waters. As different species preferentially hunt fish, worms, or molluscs they are categorized as piscivorous, vermivorous, or molluscivorous, respectively, although some cone snail species can feed on more than one prey type. These slow-moving creatures evolved into predators through incorporation of a specialized envenomation apparatus that enables them to quickly subdue their fast-moving prey. Conotoxins target a wide range of receptors and ion channels with unparalleled potency and selectivity. They have consequently become the subject of intense research in light of their immense diagnostic and therapeutic potential and are the focus of this review.

引用

页码：5815 / 5847

页数：33

共 350 条

[1] Mechanisms of conotoxin inhibition of N-type (Cav2.2) calcium channels [J].

Adams, David J. ;

Berecki, Geza .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2013, 1828 (07) :1619-1628

[2]

Akaji K., 2004, Houben-Weyl, Synthesis of Peptides and Peptidomimetics, VE22b, P101

[3] κM-conotoxin RIIIK, structural and functional novelty in a K+ channel antagonist [J].

Al-Sabi, A ;

Lennartz, D ;

Ferber, M ;

Gulyas, J ;

Rivier, JEF ;

Olivera, BM ;

Carlomagno, T ;

Terlau, H .

BIOCHEMISTRY, 2004, 43 (27) :8625-8635

[4]

Alewood P.F., 1996, Peptides: Proceedings of the Twenty-Fourth European Peptide Symposium, V183, P183

[5] Oxidative refolding chromatography:: folding of the scorpion toxin Cn5 [J].

Altamirano, MM ;

García, C ;

Possani, LD ;

Fersht, AR .

NATURE BIOTECHNOLOGY, 1999, 17 (02) :187-191

[6] Methods and Protocols of modern solid phase peptide synthesis [J].

Amblard, M ;

Fehrentz, JA ;

Martinez, J ;

Subra, G .

MOLECULAR BIOTECHNOLOGY, 2006, 33 (03) :239-254

[7] ω-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine [J].

Andersson, Asa ;

Baell, Jonathan B. ;

Duggan, Peter J. ;

Graham, Janease E. ;

Lewis, Richard J. ;

Lumsden, Natalie G. ;

Tranberg, C. Elisabet ;

Tuck, Kellie L. ;

Yang, Aijun .

BIOORGANIC & MEDICINAL CHEMISTRY, 2009, 17 (18) :6659-6670

[8] PRINCIPLES THAT GOVERN FOLDING OF PROTEIN CHAINS [J].

ANFINSEN, CB .

SCIENCE, 1973, 181 (4096) :223-230

[9] Novel solid-phase reagents for facile formation of intramolecular disulfide bridges in peptides under mild conditions [J].

Annis, I ;

Chen, L ;

Barany, G .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (29) :7226-7238

[10] α-Conotoxins [J].

Arias, HR ;

Blanton, MP .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2000, 32 (10) :1017-1028

← 1 2 3 4 5 6 7 8 9 10 →