Measurements of insulin-mediated glucose disposal are stable over time

被引:9
作者
Facchini, F
Humphreys, MH
Jeppesen, J
Reaven, GM
机构
[1] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA
[2] San Francisco Gen Hosp, Dept Med, San Francisco, CA 94110 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94110 USA
关键词
D O I
10.1210/jc.84.5.1567
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
To evaluate the stability of insulin-mediated glucose disposal, over time, we measured the steady-state plasma insulin (SSPI) and steady-state plasma glucose (SSPG) concentrations in response to a continuous infusion of SRIF (5 mu g/min), insulin (25 mu U/m(2).min), and dextrose (240 mu g/m(2).min). These measurements were made in 15 healthy volunteers, studied before and after a mean (+/-SEM) interval of 48 +/- 2 months. The mean (+/-SEM) weight of the volunteers did not increase with time (75.4 +/- 3.1 us. 76.6 +/- 3.2 kg), and there was no significant variation between the 2 mean (+/-SEM) values of either SSPI(324 +/- 18 us. 372 +/- 24 pmol/L) or SSPG (8.4 +/- 1.0 us. 8.2 +/- 1.0 mmol/L). Given the similarity of both SSPI and SSPG concentrations at baseline and follow-up, it can be concluded that insulin-mediated glucose disposal was stable in these 15 individuals over an interval of approximately 4 yr.
引用
收藏
页码:1567 / 1569
页数:3
相关论文
共 8 条
[1]   RELATIONSHIP BETWEEN DEGREE OF OBESITY AND INVIVO INSULIN ACTION IN MAN [J].
BOGARDUS, C ;
LILLIOJA, S ;
MOTT, DM ;
HOLLENBECK, C ;
REAVEN, G .
AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 248 (03) :E286-E291
[2]   ASSESSMENT OF INSULIN RESISTANCE WITH THE INSULIN SUPPRESSION TEST AND THE EUGLYCEMIC CLAMP [J].
GREENFIELD, MS ;
DOBERNE, L ;
KRAEMER, F ;
TOBEY, T ;
REAVEN, G .
DIABETES, 1981, 30 (05) :387-392
[3]   IMMUNOASSAY OF INSULIN WITH INSULIN-ANTIBODY PRECIPITATE [J].
HALES, CN ;
RANDLE, PJ .
BIOCHEMICAL JOURNAL, 1963, 88 (01) :137-&
[4]  
HARRIS M, 1979, DIABETES, V28, P1039
[5]  
KADISH AH, 1968, CLIN CHEM, V14, P116
[6]   EVALUATION OF OCTREOTIDE TO ASSESS INSULIN-MEDIATED GLUCOSE DISPOSAL BY THE INSULIN SUPPRESSION TEST [J].
PEI, D ;
JONES, CNO ;
BHARGAVA, R ;
CHEN, YDI ;
REAVEN, GM .
DIABETOLOGIA, 1994, 37 (08) :843-845
[7]   COMPARISON OF IMPEDANCE TO INSULIN-MEDIATED GLUCOSE UPTAKE IN NORMAL SUBJECTS AND IN SUBJECTS WITH LATENT DIABETES [J].
SHEN, SW ;
REAVEN, GM ;
FARQUHAR, JW .
JOURNAL OF CLINICAL INVESTIGATION, 1970, 49 (12) :2151-+
[8]   Resistance to insulin-mediated glucose disposal as a predictor of cardiovascular disease [J].
Yip, J ;
Facchini, FS ;
Reaven, GM .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (08) :2773-2776