The Rising Challenge of Non-AIDS-Defining Cancers in HIV-Infected Patients

被引：166

作者：

Deeken, John F. ^{[1
]}

Tjen-A-Looi, Angelique ^{[2
]}

Rudek, Michelle A. ^{[4
]}

Okuliar, Catherine ^{[3
]}

Young, Mary ^{[2
]}

Little, Richard F. ^{[5
]}

Dezube, Bruce J. ^{[6
]}

机构：

[1] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Div Hematol Oncol, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Div Infect Dis, Washington, DC 20007 USA

[3] Georgetown Univ, Med Ctr, Div Internal Med, Washington, DC 20007 USA

[4] Sidney Kimmel Comprehens Canc Ctr Johns Hopkins, Baltimore, MD USA

[5] NCI, Clin Invest Branch CTEP, Bethesda, MD 20892 USA

[6] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med Hematol Oncol, Boston, MA 02215 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2012年 / 55卷 / 09期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; SQUAMOUS-CELL CARCINOMA; HEPATITIS-C VIRUS; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; POSITIVE PATIENTS; HODGKIN LYMPHOMA; UNITED-STATES; BREAST-CANCER;

D O I：

10.1093/cid/cis613

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Since the advent of HAART, patients with HIV infection have seen a significant improvement in their morbidity, mortality, and life expectancy. The incidence of AIDS-defining illnesses, including AIDS-defining malignancies, has been on the decline. However, deaths due to non-AIDS-defining illnesses have been on the rise. These so-called non-AIDS-defining cancers (NADCs) include cancers of the lung, liver, kidney, anus, head and neck, and skin, as well as Hodgkin's lymphoma. It is poorly understood why this higher rate of NADCs is occurring. The key challenge facing oncologists is how to administer chemotherapy effectively and safely to patients on antiretroviral therapy. The challenge to clinicians caring for HIV-infected patients is to develop and implement effective means to screen, treat, and prevent NADCs in the future. This review presents data on the epidemiology and etiology of NADCs, as well as ongoing research into this evolving aspect of the HIV epidemic.

引用

页码：1228 / 1235

页数：8

共 88 条

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