Design and synthesis of diaminopyrrolidinone inhibitors of human osteoclast cathepsin K

被引：15

作者：

Duffy, KJ

Ridgers, LH

DesJarlais, RL

Tomaszek, TA

Bossard, MJ

Thompson, SK

Keenan, RM

Veber, DF

机构：

[1] SmithKline Beecham Pharmaceut, Dept Med Chem, Collegeville, PA 19426 USA

[2] SmithKline Beecham Pharmaceut, Dept Mol Recognit, Collegeville, PA 19426 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(99)00322-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-based design and synthesis of lactam-constrained azapeptide inhibitors of human cathepsin K are described. Enhanced stability to proteolytic cleavage over acyclic analogues is discussed. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：1907 / 1910

页数：4

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