STIM-ORAI Interactions That Control the CRAC Channel

被引：41

作者：

Gudlur, Aparna ^{[1
]}

Zhou, Yubin ^{[1
,2
]}

Hogan, Patrick G. ^{[1
]}

机构：

[1] La Jolla Inst Allergy & Immunol, La Jolla, CA USA

[2] Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Ctr Translat Canc Res, Houston, TX USA

来源：

STORE-OPERATED CALCIUM CHANNELS | 2013年 / 71卷

关键词：

STROMAL INTERACTION MOLECULE-1; STORE-INDEPENDENT MODES; OPERATED CALCIUM-ENTRY; CA2+ SENSOR; CA2+-DEPENDENT INACTIVATION; MECHANISTIC INSIGHTS; CRYSTAL-STRUCTURE; ION SELECTIVITY; COILED-COIL; N-TERMINUS;

D O I：

10.1016/B978-0-12-407870-3.00002-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Ca2+ sensor STIM1 and the Ca2+ channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca2+ entry. This chapter focuses on the protein-protein interactions of STIM and ORAI proteins that control the channel.

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页码：33 / 58

页数：26

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