Human papillomavirus type 16 E2-specific T-helper lymphocyte responses in patients with cervical intraepithelial neoplasia

被引:38
作者
Bontkes, HJ
de Gruijl, TD
Bijl, A
Verheijen, RHM
Meijer, CJLM
Scheper, RJ
Stern, PL
Burns, JE
Maitland, NJ
Walboomers, JMM
机构
[1] Free Univ Amsterdam Hosp, Dept Pathol, NL-1007 MB Amsterdam, Netherlands
[2] Free Univ Amsterdam Hosp, Dept Obstet & Gynaecol, NL-1007 MB Amsterdam, Netherlands
[3] Christie Hosp NHS Trust, Paterson Inst Canc Res, Dept Immunol, Manchester M20 4BX, Lancs, England
[4] Univ York, YCR Canc Res Unit, Dept Biol, York YO1 5DD, N Yorkshire, England
关键词
D O I
10.1099/0022-1317-80-9-2453
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
T-cell-mediated immune responses against mucosal oncogenic types of human papillomaviruses (HPV) are thought to play a role in the control of the virus infection and its associated cervical lesions. The in vitro production of interleukin-2 by T-helper (Th) cells in response to the C-terminal and N-terminal domains of the HPV-16 E2 protein was determined in 74 women with cytological evidence of premalignant cervical epithelial neoplasia who participated in a non-intervention follow-up (FU) study, Cross-sectional analysis at the end of FU showed that Th cell responses against the C-terminal domain were associated with evidence of previous or present HPV-16 infection as compared to patients with no evidence of any HPV infection (18.9% versus 0%, P = 0.039). Th cell responses against the N-terminal domain were not associated with evidence of HPV-16 infection. No association with disease outcome was observed with Th cell responses against either of the E2 protein domains. However, longitudinal analysis revealed that Th cell responses against the C-terminal domain frequently occur at the time of virus clearance. Whether these responses are responsible for the clearance of the virus is not known.
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收藏
页码:2453 / 2459
页数:7
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