Molecular analysis of an HBsAg-negative hepatitis B virus mutant selected in a tenofovir-treated HIV-hepatitis B virus co-infected patient

被引：20

作者：

Amini-Bavil-Olyaee, Samad ^{[1
]}

Sheldon, Julie ^{[2
]}

Lutz, Thomas ^{[3
]}

Trautwein, Christian ^{[1
]}

Tacke, Frank ^{[1
]}

机构：

[1] Univ Hosp Aachen, Rhein Westfal TH Aachen, Dept Med 3, D-52074 Aachen, Germany

[2] Hosp Carlos III, Madrid, Spain

[3] Infektiologikum, Frankfurt, Germany

来源：

AIDS | 2009年 / 23卷 / 02期

关键词：

REPLICATION; MUTATIONS; RESISTANCE; PROMOTER; THERAPY; GENOME; EXPRESSION;

D O I：

10.1097/QAD.0b013e3283224316

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The molecular analysis performed in an HIV-hepatitis B virus (HBV) coinfected patient revealed selection of an unusual HBV polymerase mutation (rtV191I) during tenofovir-containing therapy, conferring simultaneously immune escape by HBsAg negativity and resistance to lamivudine but not tenofovir. Phenotypic analysis revealed impaired replicative capacity of mutants, which could be restored by concomitant precore or basal core promoter mutations (HBe-antigen-negativity). HBV mutants carrying drug and vaccine resistance may represent a considerable individual risk and public health concern.

引用

页码：268 / 272

页数：5

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