New avenues for anti-inflammatory therapy

被引：6

作者：

Mackay, CR ^{[1
]}

机构：

[1] St Vincents Hosp, Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia

来源：

NATURE MEDICINE | 2002年 / 8卷 / 02期

关键词：

D O I：

10.1038/nm0202-117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new study identifies the chemokine CCL27 and its receptor CCR10 as important homing molecules for T-cell migration to the skin. Moreover, they find that CCL27 inhibition suppresses some skin-inflammatory responses, suggesting that therapies targeting CCL10 could be used to treat several human skin disorders. (pages 157–165)

引用

页码：117 / 118

页数：2

共 8 条

[1] Lymphocyte homing and homeostasis [J].

Butcher, EC ;

Picker, LJ .

SCIENCE, 1996, 272 (5258) :60-66

[2] LEUKOCYTE-ENDOTHELIAL CELL RECOGNITION - 3 (OR MORE) STEPS TO SPECIFICITY AND DIVERSITY [J].

BUTCHER, EC .

CELL, 1991, 67 (06) :1033-1036

[3] Rapid acquisition of tissue-specific homing phenotypes by CD4+ T cells activated in cutaneous or mucosal lmphoid tissues [J].

Campbell, DJ ;

Butcher, EC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (01) :135-141

[4] The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells [J].

Campbell, JJ ;

Haraldsen, G ;

Pan, J ;

Rottman, J ;

Qin, S ;

Ponath, P ;

Andrew, DP ;

Warnke, R ;

Ruffing, N ;

Kassam, N ;

Wu, L ;

Butcher, EC .

NATURE, 1999, 400 (6746) :776-780

[5] CCL27-CCR10 interactions regulate T cell-mediated skin inflammation [J].

Homey, B ;

Alenius, H ;

Müller, A ;

Soto, H ;

Bowman, EP ;

Yuan, W ;

McEvoy, L ;

Lauerma, AI ;

Assmann, T ;

Bünemann, E ;

Lehto, M ;

Wolff, H ;

Yen, D ;

Marxhausen, H ;

To, W ;

Sedgwick, J ;

Ruzicka, T ;

Lehmann, P ;

Zlotnik, A .

NATURE MEDICINE, 2002, 8 (02) :157-165

[6] CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells [J].

Morales, J ;

Homey, B ;

Vicari, AP ;

Hudak, S ;

Oldham, E ;

Hedrick, J ;

Orozco, R ;

Copeland, NG ;

Jenkins, NA ;

McEvoy, LM ;

Zlotnik, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (25) :14470-14475

[7] CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin [J].

Reiss, Y ;

Proudfoot, AE ;

Power, CA ;

Campbell, JJ ;

Butcher, EC .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (10) :1541-1547

[8] Advances in immunology: T-cell function and migration - Two sides of the same coin [J].

von Andrian, UH ;

Mackay, CR .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (14) :1020-1033

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