Early and nonreversible decrease of CD161++/MAIT cells in HIV infection

被引：246

作者：

Cosgrove, Cormac ^{[1
]}

Ussher, James E. ^{[1
]}

Rauch, Andri ^{[2
,3
]}

Gaertner, Kathleen ^{[4
]}

Kurioka, Ayako ^{[1
]}

Huehn, Michael H. ^{[5
]}

Adelmann, Krista ^{[1
]}

Kang, Yu-Hoi ^{[1
]}

Fergusson, Joannah R. ^{[1
]}

Simmonds, Peter ^{[4
]}

Goulder, Philip ^{[1
]}

Hansen, Ted H. ^{[6
]}

Fox, Julie ^{[7
]}

Guenthard, Huldrych F. ^{[8
]}

Khanna, Nina ^{[9
]}

Powrie, Fiona ^{[5
]}

Steel, Alan ^{[10
]}

Gazzard, Brian ^{[10
]}

Phillips, Rodney E. ^{[1
]}

Frater, John ^{[1
]}

Uhlig, Holm ^{[5
]}

Klenerman, Paul ^{[1
]}

机构：

[1] Univ Oxford, Biomed Res Ctr, Natl Inst Hlth Res, Oxford, England

[2] Univ Hosp Bern, Div Infect Dis, CH-3010 Bern, Switzerland

[3] Univ Bern, Bern, Switzerland

[4] Ashworth Labs, Ctr Immunol Infect & Evolut, Edinburgh, Midlothian, Scotland

[5] Univ Oxford, Translat Gastroenterol Unit, Oxford, England

[6] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO USA

[7] Kings Coll London, St Thomas Hosp, Guys & St Thomas Natl Hlth Serv Trust, London WC2R 2LS, England

[8] Univ Zurich, Univ Zurich Hosp, Div Infect Dis & Hosp Epidemiol, Zurich, Switzerland

[9] Univ Basel Hosp, Div Infect Dis, CH-4031 Basel, Switzerland

[10] Chelsea & Westminster Hosp, St Stephens Ctr, London, England

来源：

BLOOD | 2013年 / 121卷 / 06期

基金：

英国惠康基金; 英国医学研究理事会; 瑞士国家科学基金会;

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; CYTOTOXIC T-LYMPHOCYTES; INTESTINAL PERMEABILITY; IMMUNE ACTIVATION; CD161; EXPRESSION; LYMPHOID-TISSUE; DEPLETION; RESTORATION; SUBSETS; DISEASE;

D O I：

10.1182/blood-2012-06-436436

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

HIV infection is associated with immune dysfunction, perturbation of immune-cell subsets and opportunistic infections. CD161(++)CD8(+) T cells are a tissue-infiltrating population that produce IL17A, IL22, IFN gamma, and TNF alpha, cytokines important in mucosal immunity. In adults they dominantly express the semi-invariant TCR V alpha 7.2, the canonical feature of mucosal associated invariant T (MAIT) cells and have been recently implicated in host defense against pathogens. We analyzed the frequency and function of CD161(++)/MAIT cells in peripheral blood and tissue from patients with early stage or chronic-stage HIV infection. We show that the CD161(++)/MAIT cell population is significantly decreased in early HIV infection and fails to recover despite otherwise successful treatment. We provide evidence that CD161(++)/MAIT cells are not preferentially infected but may be depleted through diverse mechanisms including accumulation in tissues and activation-induced cell death. This loss may impact mucosal defense and could be important in susceptibility to specific opportunistic infections in HIV. (Blood. 2013;121(6):951-961)

引用

页码：951 / 961

页数：11

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