CD80 antigen expression as a predictor of ex vivo chemosensitivity in chronic lymphocytic leukemia

被引：4

作者：

Kivekäs, I

Hulkkonen, J

Hurme, M

Vilpo, L

Vilpo, J

机构：

[1] Tampere Univ Hosp, Dept Clin Chem, Lab Ctr, Leukemia Res Lab, FIN-33521 Tampere, Finland

[2] Univ Tampere, Sch Med, FIN-33521 Tampere, Finland

[3] Tampere Univ Hosp, Lab Ctr, Dept Clin Microbiol, Tampere, Finland

来源：

LEUKEMIA RESEARCH | 2002年 / 26卷 / 05期

关键词：

chemosensitivity; purine analogs; cluster of differentiation; CD80; chronic lymphocytic leukemia;

D O I：

10.1016/S0145-2126(01)00159-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the correlation between expression of 31 surface membrane antigens and chemosensitivity of peripheral blood mononuclear cells from 36 patients with CLL. The sensitivity of CLL cells to nine drugs (2'-chlorodeoxyadenosine, cisplatin, chlorambucil, cyclosporin A, doxorubicin, fludarabinc, prednisolone, verapamil and vincristine) and two types of irradiation (gamma and UV-irradiation) was determined from dose-response curves of 4-day cultures ex vivo. The results indicated that the CLL cases responding to purine analogs (2'-chlorodeoxyadenosiric and fludarabine) can be identified according to CD80 expression: all resistant cases had low or negative CD80 expression. No other correlations were revealed. CDSO may be a surrogate chemosensitivity marker for purine analogs. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：443 / 446

页数：4

共 6 条

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