The genetics of intervertebral disc degeneration. Associated genes

被引：123

作者：

Kalichman, Leonid ^{[1
]}

Hunter, David J. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Clin Epidemiol Res & Training Unit, Boston, MA 02118 USA

来源：

JOINT BONE SPINE | 2008年 / 75卷 / 04期

关键词：

intervertebral disc; heritability; gene; spine;

D O I：

10.1016/j.jbspin.2007.11.002

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

Objectives: To review current knowledge on genes associated with intervertebral disk degeneration. Methods: A literature-based narrative review of the English language medical literature. Results and conclusions: There are a number of genes that have been associated with intervertebral disk degeneration in humans, including genes coding for collagen I, collagen IX (COL9A2 and COL9A3), collagen XI (COL11A2), IL-1, aggrecan, vitamin D receptor, MMP-3, and CILP. For specific genes and some environmental factors, gene-gene, gene-environment and gene-age interactions may exist. Candidate-gene association studies have limitations in detecting the genetic basis of the disease because this approach relies on having predicted the correct genes on the basis of a biological hypothesis or the location of known linkage regions. Additional studies, including linkage analyses and whole genome scan studies in different populations and whole range of ages, are required to improve our understanding of the influence of the aforementioned genes on intervertebral disk degeneration and identify novel genes. (c) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：388 / 396

页数：9

共 68 条

[1]

An allele of COL9A2 associated with intervertebral disc disease [J].