Expression analysis of PDGF-C in adult and developing mouse tissues

被引：55

作者：

Aase, K

Abramsson, A

Karlsson, L

Betsholtz, C

Eriksson, U

机构：

[1] Ludwig Inst Canc Res, S-17177 Stockholm, Sweden

[2] Univ Gothenburg, Dept Biochem Med, S-40530 Gothenburg, Sweden

来源：

MECHANISMS OF DEVELOPMENT | 2002年 / 110卷 / 1-2期

关键词：

PDGF-A; PDGF-B; PDGF-C; PDGFR-alpha; PDGFR-beta; mouse; embryo; development; in situ hybridization; immunohistochemistry; expression; pattern; CUB domain; morphogenesis; somite; mesenchyme; smooth muscle cell; epithelium; chondrocyte; kidney;

D O I：

10.1016/S0925-4773(01)00560-3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There are four members of the platelet-derived growth factor (PDGF) family; PDGF-A, PDGF-B, PDGF-C and PDGF-D. Their biological effects are mediated via two tyrosine kinase receptors, PDGFR-alpha and PDGFR-beta, and PDGF-mediated signaling is critical for development of many organ systems. Analysis in adult tissues showed that PDGF-C was mainly expressed in kidney, testis, liver, heart and brain. During development, PDGF-C expression was widespread and dynamic, and found in somites and their derivatives, in kidney, lung, brain, and in several other tissues, particularly at sites of developing epidermal openings. PDGF-C may therefore have unique functions during tissue development and maintenance. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：187 / 191

页数：5

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