Retinoblastoma protein meets chromatin

被引：123

作者：

Brehm, A ^{[1
]}

Kouzarides, T ^{[1
]}

机构：

[1] Univ Cambridge, Wellcome CRC Inst, Dept Pathol, Cambridge CB2 1QR, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1999年 / 24卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0968-0004(99)01368-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The retinoblastoma (RB) protein exerts its tumour-suppressor function by repressing the transcription of cellular genes required for DNA replication and cell division. Recent investigations into the mechanism of RE repression have revealed that RE can regulate transcription by effecting changes in chromatin structure. These findings point towards a link between chromatin regulation and cancer.

引用

页码：142 / 145

页数：4

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