The Mouse Forced Swim Test

被引：486

作者：

Can, Adem ^{[1
]}

Dao, David T. ^{[2
]}

Arad, Michal ^{[1
]}

Terrillion, Chantelle E. ^{[3
]}

Piantadosi, Sean C. ^{[1
]}

Gould, Todd D. ^{[1
,3
,4
]}

机构：

[1] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA

[2] Tulane Univ, Sch Med, New Orleans, LA 70118 USA

[3] Univ Maryland, Sch Med, Dept Pharmacol & Expt Therapeut, Baltimore, MD USA

[4] Univ Maryland, Program Neurosci, Baltimore, MD USA

来源：

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS | 2012年 / 59期

关键词：

Neuroscience; Issue; 59; animal models; behavioral analysis; neuroscience; neurobiology; mood disorder; depression; mood stabilizer; antidepressant; forced swimming test; FST; BEHAVIORAL DESPAIR; STRAIN DIFFERENCES; ANIMAL-MODELS; MICE; ANTIDEPRESSANTS; DEPRESSION; ANXIETY; LITHIUM;

D O I：

10.3791/3638

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice are placed in an inescapable transparent tank that is filled with water and their escape related mobility behavior is measured. The forced swim test is straightforward to conduct reliably and it requires minimal specialized equipment. Successful implementation of the forced swim test requires adherence to certain procedural details and minimization of unwarranted stress to the mice. In the protocol description and the accompanying video, we explain how to conduct the mouse version of this test with emphasis on potential pitfalls that may be detrimental to interpretation of results and how to avoid them. Additionally, we explain how the behaviors manifested in the test are assessed.

引用

页数：6

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