Podoplanin:: A novel diagnostic immunohistochemical marker

被引：136

作者：

Ordóñez, NG ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2006年 / 13卷 / 02期

关键词：

podoplanin; D2-40; lymphatic endothelium; mesothelioma; seminoma;

D O I：

10.1097/01.pap.0000213007.48479.94

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Podoplanin is a transmembrane mucoprotein recognized by the recently commercially available D2-40 monoclonal antibody. Recent investigations have shown that podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Podoplanin has also been shown to be strongly expressed in seminomas, epithelioid mesotheliomas, and hemangioblastomas, and immunostaining for this marker can assist in the diagnosis of these tumors. This article reviews the Current information oil the applications of podoplanin immunostaining in surgical pathology.

引用

页码：83 / 88

页数：6

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