Hypothesis:: from epidermal barrier dysfunction to atopic disorders

被引:97
作者
Taïeb, A [1 ]
机构
[1] Hop Pellegrin, Pediat Dermatol Unit, F-33076 Bordeaux, France
关键词
atopic dermatitis; epidermal barrier dysfunction; irritants; allergens; atopens; genetic basis; candidate genes; patch testing;
D O I
10.1111/j.1600-0536.1999.tb06125.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
The role of a genetically-impaired epidermal barrier as the primary cause of the rapid increase in prevalence of atopic dermatitis and respiratory atopy is proposed, based on available clinical and experimental data. The subsequently increased exposure to irritants and allergen postnatally in predisposed individuals would lead in a subset of these to a specific TH(2) cell activation favouring the development of IgE responses to atopens. Other routes of sensitization are probably important, but skin offers a good target to implement prevention strategies, so far completely ignored in the prophylactic recommendations given to high-risk families. Candidate genes for skin-barrier impairment are possibly those associated with ichthyosis vulgaris and X-linked hypohidrotic ectodermal dysplasia.
引用
收藏
页码:177 / 180
页数:4
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