Synthesis and biological evaluation of new dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraones, substituted with various saturated and unsaturated side chains via palladium catalyzed cross-coupling reactions

被引：24

作者：

Henon, Helene

Anizon, Fabrice

Golsteyn, Roy M.

Leonce, Stephane

Hofmann, Robert

Pfeiffer, Bruno

Prudhomme, Michelle ^{[1
]}

机构：

[1] Univ Clermont Ferrand, Lab SEESIB, UMR 6504, CNRS, F-63177 Aubiere, France

[2] SERVIER, Inst Rech, Div Rech Cancerol, F-78290 Croissy Sur Seine, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 11期

关键词：

isogranulatimide; antitumor agents; dipyrrolo[3,4-a : 3,4c]carbazole-1,3,4,6-tetraone; Chk1; inhibitors;

D O I：

10.1016/j.bmc.2006.01.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The syntheses of a series of dipyrrolo[3,4-a:3,4-c]carbazole-1,3,4,6-tetraoties, substituted in 10-position with saturated and unsaturated side chains, via palladium catalyzed cross-coupling reactions, are described. These compounds call be considered as granulatimide bis-imide analogues. Their inhibitory activity toward Chk1 kinase and their antiproliferative activities in vitro in four tumor cell lines are reported. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3825 / 3834

页数：10

共 27 条

[1]

Andersen R. J., 1999, Chem. Abstr., Patent No. [WO 9947522A1, 9947522, W099/47522, CA 131: 243451]

[2]

ANDERSEN RJ, 1999, Patent No. 131243451

[3]

Anderson Hilary J, 2003, Prog Cell Cycle Res, V5, P423

[4] Acid-induced dimerization of 3-(1H-indol-3-yl)maleimides.: Formation of cyclopentindole derivatives [J].