Infectious and noninfectious amyloids of the HET-s(218-289) prion have different NMR spectra

被引：40

作者：

Wasmer, Christian ^{[1
]}

Soragni, Alice ^{[1
]}

Sabate, Raimon ^{[2
]}

Lange, Adam ^{[1
]}

Riek, Roland ^{[1
]}

Meier, Beat H. ^{[1
]}

机构：

[1] ETH, Phys Chem Lab, CH-8093 Zurich, Switzerland

[2] Univ Bordeaux 2, Lab Genet Mol Champignons, IBGC UMR CNRS 5095, F-33076 Bordeaux, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 31期

关键词：

amyloids; fibrils; NMR spectroscopy; protein structures; structural biology;

D O I：

10.1002/anie.200704896

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Graph Presented) The molecular basis for prion infectivity is not yet understood. The NMR spectra of noninfectious and infectious amyloids of the prion-forming domain 218-289 of the fungal prion HET-s are clearly different (see picture) but are indicative for a cross-β arrangement in both cases. The fibrils formed at pH 3 are not infectious because their molecular structure apparently differs substantially from that formed at physiological pH. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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收藏

页码：5839 / 5841

页数：3

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