Patients with Alzheimer disease have elevated intrathecal synthesis of antibodies against tau protein and heavy neurofilament

被引：44

作者：

Bartos, Ales ^{[1
,2
]}

Fialova, Lenka ^{[3
,4
]}

Svarcova, Jana ^{[3
,4
]}

Ripova, Daniela ^{[1
]}

机构：

[1] Prague Psychiat Ctr, AD Ctr, Prague 18103 8, Czech Republic

[2] Charles Univ Prague, Fac Med 3, Univ Hosp Kralovske Vinohrady, Dept Neurol, Prague 10034 10, Czech Republic

[3] Charles Univ Prague, Fac Med 1, Prague 12108 2, Czech Republic

[4] Gen Teaching Hosp, Inst Med Biochem & Lab Diagnost, Prague 12108 2, Czech Republic

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 252卷 / 1-2期

关键词：

Alzheimer disease; Serum; Cerebrospinal fluid; Antibody; Tau protein; Neurofilament; ADDENBROOKES COGNITIVE EXAMINATION; CEREBROSPINAL-FLUID BIOMARKERS; MULTIPLE-SCLEROSIS; NEURODEGENERATIVE DISEASES; NEUROFIBRILLARY TANGLES; TASK-FORCE; AUTOANTIBODIES; DEMENTIA; DIAGNOSIS; IMMUNOTHERAPY;

D O I：

10.1016/j.jneuroim.2012.08.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The role of humoral immunity related to neuron- and disease-specific cytoskeletal proteins patients with Alzheimer disease (AD) is unknown. We measured antibodies against tau protein, light and heavy (NFH) neurofilaments using ELISA in 80 paired serum and cerebrospinal fluid (CSF) samples from patients with AD, with other dementias (OD), with neuro-inflammatory diseases (IC) and 25 controls (NC). We estimated intrathecal synthesis according to the formula (CSF/serum anti-neurocytoskeletal IgG)/(CSF/serum total IgG). AD patients had significantly higher intrathecal anti-tau and anti-NFH antibodies than the other groups. These innovative findings may hint at specific alterations in humoral anti-neurocytoskeletal immunity and selectivity in AD, which could have diagnostic and immunotherapeutic implications. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：100 / 105

页数：6

共 57 条

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