Oncogenic human papillomavirus infection and cervical lesions in aboriginal women of Nunavut, Canada

被引:39
作者
Healey, SM
Aronson, KJ
Mao, Y
Schlecht, NF
Mery, LS
Ferenczy, A
Franco, EL
机构
[1] McGill Univ, Dept Oncol, Montreal, PQ H2W 1S6, Canada
[2] Nunavut Dept Hlth, Hlth Protect Unit, Iqaluit, NU, Canada
[3] McGill Univ, Dept Epidemiol, Montreal, PQ H2W 1S6, Canada
[4] McGill Univ, Dept Pathol, Montreal, PQ H2W 1S6, Canada
[5] McGill Univ, Dept Obstet & Gynecol, Montreal, PQ H2W 1S6, Canada
[6] Queens Univ, Dept Community Hlth & Epidemiol, Kingston, ON, Canada
[7] Hlth Canada, Populat & Publ Hlth Branch, Ctr Chron Dis Prevent & Control, Canc Bur,Environm Risk Assessment & Case Surveill, Ottawa, ON K1A 0L2, Canada
关键词
D O I
10.1097/00007435-200112000-00006
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background. The high rate of cervical cancer among aboriginal women of northern Canada has prompted the search for more aggressive methods to augment Papanicolaou (Pap) screening in this population. Nearly all cervical cancers result from oncogenic human papillomavirus (HPV) infections. This has generated interest for incorporating HPV testing into the current screening program. Goals: To determine the prevalence of oncogenic HPVs in Nunavut, and to assess the association between HPV and squamous intraepithelial lesions (SIL). Study Design: A cross-sectional study was conducted on the Pap-screened populations in 19 communities of Nunavut, Canada. Liquid-based cytology was used to screen for SIL. HPV testing was performed using the Hybrid Capture II assay. Correlates of HPV infection and SIL were assessed by logistic regression with control for potential confounders. Results: In 1290 women ages 13 to 79 years, the prevalence rate was 26% for oncogenic HPV and 6.9% for SIL. The odds ratio for the association between HPV and SIL was 37.9 (95% CI, 17.7-80.8) after multivariate adjustment. This association increased markedly with increasing viral load. More than 90% of the women with squamous intraepithelial lesions had positive test results for HPV. More than 75% of the women who had positive test results for HPV but negative test results for SIL were younger than 30 years. Conclusion: The results of this study form the basis for further evaluation of the role that liquid-based cytology and HPV testing plays and will contribute to the strategy for cervical cancer prevention in Nunavut.
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页码:694 / 700
页数:7
相关论文
共 39 条
  • [1] [Anonymous], AHCPR PUBLICATION
  • [2] CERVICAL PAPILLOMAVIRUS INFECTION AND CERVICAL DYSPLASIA IN HISPANIC, NATIVE-AMERICAN, AND NON-HISPANIC WHITE WOMEN IN NEW-MEXICO
    BECKER, TM
    WHEELER, CM
    MCGOUGH, NS
    JORDAN, SW
    DORIN, M
    MILLER, J
    [J]. AMERICAN JOURNAL OF PUBLIC HEALTH, 1991, 81 (05) : 582 - 586
  • [3] RISK-FACTORS FOR CERVICAL-CANCER IN COLOMBIA AND SPAIN
    BOSCH, FX
    MUNOZ, N
    DESANJOSE, S
    IZARZUGAZA, I
    GILI, M
    VILADIU, P
    TORMO, MJ
    MOREO, P
    ASCUNCE, N
    GONZALEZ, LC
    TAFUR, L
    KALDOR, JM
    GUERRERO, E
    ARISTIZABAL, N
    SANTAMARIA, M
    DERUIZ, PA
    SHAH, K
    [J]. INTERNATIONAL JOURNAL OF CANCER, 1992, 52 (05) : 750 - 758
  • [4] Hybrid Capture II-based human papillomavirus detection, a sensitive test to detect in routine high-grade cervical lesions: a preliminary study on 1518 women
    Clavel, C
    Masure, M
    Bory, JP
    Putaud, I
    Mangeonjean, C
    Lorenzato, M
    Gabriel, R
    Quereux, C
    Birembaut, P
    [J]. BRITISH JOURNAL OF CANCER, 1999, 80 (09) : 1306 - 1311
  • [5] Analysis of false-negative and underreported smears in the Florence District screening program for cervical carcinoma
    Confortini, M
    Ciatto, S
    Bonardi, L
    Bulgaresi, P
    Cariaggi, MP
    Carozzi, F
    Cipparrone, G
    Minuti, PA
    Rubeca, T
    Biggeri, A
    [J]. TUMORI, 1997, 83 (06) : 880 - 883
  • [6] Corriveau A., 1997, EPI N, V9, P5
  • [7] A systematic review of the role of human papilloma virus (HPV) testing within a cervical screening programme: summary and conclusions
    Cuzick, J
    Sasieni, P
    Davies, P
    Adams, J
    Normand, C
    Frater, A
    van Ballegooijen, M
    van den Akker-van Marle, E
    [J]. BRITISH JOURNAL OF CANCER, 2000, 83 (05) : 561 - 565
  • [8] INCIDENCE OF INVASIVE CERVICAL-CANCER PRECEDED BY NEGATIVE SCREENING IN HIGH-RISK ALASKA NATIVE WOMEN
    DAVIDSON, M
    BULKOW, LR
    LANIER, AP
    SMITH, RA
    HAWKINS, I
    JENSEN, H
    KIVIAT, N
    [J]. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1994, 23 (02) : 238 - 245
  • [9] Ferenczy A, 1996, AM J OBSTET GYNECOL, V175, P651
  • [10] Cervical-cancer screening beyond the year 2000
    Ferenczy, Alex
    Franco, Eduardo
    [J]. LANCET ONCOLOGY, 2001, 2 (01) : 27 - 32