Disturbed eating at high altitude: influence of food preferences, acute mountain sickness and satiation hormones

被引:42
作者
Aeberli, Isabelle [1 ,2 ]
Erb, Annina [2 ]
Spliethoff, Kerstin [3 ,4 ]
Meier, Daniela [3 ]
Goetze, Oliver [4 ,5 ]
Fruehauf, Heiko [5 ]
Fox, Mark [4 ,5 ,6 ]
Finlayson, Graham S. [7 ]
Gassmann, Max [3 ,4 ,8 ]
Berneis, Kaspar [1 ,4 ]
Maggiorini, Marco [4 ,9 ]
Langhans, Wolfgang [4 ,10 ]
Lutz, Thomas A. [3 ,4 ]
机构
[1] Univ Zurich Hosp, Div Endocrinol Diabet & Clin Nutr, CH-8091 Zurich, Switzerland
[2] ETH, Human Nutr Lab, Zurich, Switzerland
[3] Univ Zurich, Inst Vet Physiol, Vetsuisse Fac, Zurich, Switzerland
[4] Ctr Integrat Human Physiol, Zurich, Switzerland
[5] Univ Zurich Hosp, Div Gastroenterol & Hepatol, CH-8091 Zurich, Switzerland
[6] Nottingham Digest Dis Ctr, NIHR Biomed Res Unit, Nottingham NG7 2UH, England
[7] Univ Leeds, Inst Psychol Sci, Biopsychol Grp, Fac Med Dent & Hlth, Leeds LS2 9JT, W Yorkshire, England
[8] Univ Peruana Cayetano Heredia, Lima, Peru
[9] Univ Zurich Hosp, Div Pulm, CH-8091 Zurich, Switzerland
[10] ETH, Physiol & Behav Lab, Zurich, Switzerland
关键词
Hypoxia; Dietary intake; Food preferences; High altitude; Acute mountain sickness; PANCREATIC GLUCAGON; OPERATION EVEREST; BODY-COMPOSITION; PULMONARY-EDEMA; ENERGY-INTAKE; APPETITE; RATS; HYPOXIA; EXPOSURE; WEIGHT;
D O I
10.1007/s00394-012-0366-9
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Hypoxia has been shown to reduce energy intake and lead to weight loss, but the underlying mechanisms are unclear. The aim was therefore to assess changes in eating after rapid ascent to 4,559 m and to investigate to what extent hypoxia, acute mountain sickness (AMS), food preferences and satiation hormones influence eating behavior. Participants (n = 23) were studied at near sea level (Zurich (ZH), 446 m) and on two days after rapid ascent to Capanna Margherita (MG) at 4,559 m (MG2 and MG4). Changes in appetite, food preferences and energy intake in an ad libitum meal were assessed. Plasma concentrations of cholecystokinin, peptide tyrosine-tyrosine, gastrin, glucagon and amylin were measured. Peripheral oxygen saturation (SpO(2)) was monitored, and AMS assessed using the Lake Louis score. Energy intake from the ad libitum meal was reduced on MG2 compared to ZH (643 +/- A 308 vs. 952 +/- A 458 kcal, p = 0.001), but was similar to ZH on MG4 (890 +/- A 298 kcal). Energy intake on all test days was correlated with hunger/satiety scores prior to the meal and AMS scores on MG2 but not with SpO(2) on any of the 3 days. Liking for high-fat foods before a meal predicted subsequent energy intake on all days. None of the satiation hormones showed significant differences between the 3 days. Reduced energy intake after rapid ascent to high altitude is associated with AMS severity. This effect was not directly associated with hypoxia or changes in gastrointestinal hormones. Other peripheral and central factors appear to reduce food intake at high altitude.
引用
收藏
页码:625 / 635
页数:11
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