Ontogeny of CD40 expression by activated peripheral blood lymphocytes in humans

被引：10

作者：

Brugnoni, D

Airo, P

Graf, D

Marconi, M

Molinari, C

Braga, D

Malacarne, F

Soresina, A

Ugazio, AG

Cattaneo, R

Kroczek, RA

Notarangelo, LD

机构：

[1] SPEDALI CIVIL BRESCIA,CLIN IMMUNOL SERV,I-25123 BRESCIA,ITALY

[2] ROBERT KOCH INST,W-1000 BERLIN,GERMANY

[3] UNIV PAVIA,DEPT PEDIAT,I-27100 PAVIA,ITALY

[4] UNIV BRESCIA,DEPT PEDIAT,I-25123 BRESCIA,ITALY

来源：

IMMUNOLOGY LETTERS | 1996年 / 49卷 / 1-2期

关键词：

CD40L; neonate; ontogeny of the immune system; memory cell;

D O I：

10.1016/0165-2478(95)02468-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CD40 ligand (CD40L) is a molecule expressed by activated T cells which plays a critical role in the regulation of B-cell responses, including differentiation into Ig-producing cells. Using the specific monoclonal antibody TRAP1 we have evaluated the ontogeny of CD40L expression in 97 normal individuals between birth and 50 years of age. The expression of CD40L is a function of age; it is severely reduced at birth, progressively increases during the first months of life, and reaches a plateau in the second decade. This progressive attainment of the ability to express CD40L is due to a process of maturation of the CD4 + subset, being significantly correlated with the expression of the CD45R0 antigen.

引用

页码：27 / 30

页数：4

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