Sibling and parental history in type 2 diabetes risk among ethnic Chinese: the Chin-Shan Community Cardiovascular Cohort Study

被引：12

作者：

Chien, Kuo-Liong ^{[1
,2
]}

Hsu, Hsiu-Ching ^{[1
]}

Su, Ta-Chen ^{[1
]}

Chang, Wei-Tien ^{[4
]}

Chen, Pei-Chun ^{[3
]}

Chen, Ming-Fong ^{[1
]}

Lee, Yuan-Teh ^{[1
]}

机构：

[1] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[2] Natl Taiwan Univ, Inst Prevent Med, Taipei 10764, Taiwan

[3] Natl Taiwan Univ, Coll Publ Hlth, Inst Environm Med, Taipei 10764, Taiwan

[4] Natl Taiwan Univ Hosp, Dept Emergency Med, Taipei 100, Taiwan

来源：

EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2008年 / 15卷 / 06期

关键词：

Chinese; cohort; diabetes; family history;

D O I：

10.1097/HJR.0b013e32830fe451

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background This study aims to compare various family history profiles as predictors of diabetes in a community-based prospective cohort because few prospective studies have examined the association of family history with diabetes risk in ethnic Chinese populations. Methods Among 2960 participants free from baseline diabetes through the Chin-Shan Community Cardiovascular Cohort Study, there were 548 cases that developed diabetes after a median 9 years of follow-up. Results After multivariate adjustment, sibling history was associated with diabetes [Relative risk (RR): 2.08, 95% confidence interval (CI): 1.42-3.06, P=0.0002]. Both maternal and paternal histories had similar effects (RR: 1.62, 95% CI: 1.04-2.51 for paternal history, RR: 1.36, 95% CI: 0.98-1.89 for maternal history). Obese participants with sibling history increased the risk of diabetes by 4.6-fold (RR: 4.61, 95% CI: 2.93-7.26), compared with those with neither obesity nor family history. Conclusion The findings support the hypothesis that sibling history is more important than parental history for diabetes risk. Eur J Cardiovasc Prev Rehabil 15:657-662 (C) 2008 The European Society of Cardiology

引用

页码：657 / 662

页数：6

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