Inhibition of immunoglobulin E production by Poncirus trifoliata fruit extract

被引：42

作者：

Kim, HM

Kim, HJ

Park, ST

机构：

[1] Department of Oriental Pharmacy, Coll. Pharm., Wonkwang Univ., C., Iksan-city

[2] Department of Anatomy, Sch. Med., Wonkwang Univ., C., Iksan-city

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1999年 / 66卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

IgE; immunization; Poncirus trifoliata; Rutaceae; U266 human IgE-bearing B cells;

D O I：

10.1016/S0378-8741(99)00028-8

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Immunoglobulin E (IgE) is the principal immunoglobulin involved in immediate hypersensitivities and chronic allergic diseases. The effect of an aqueous extract of Poncirus trifoliata (L) Raf. (Rutaceae) fruits (PTFE) on in vivo and in vitro IgE production was investigated. PTFE dose-dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin, Bordetella pertussis toxin and aluminum hydroxide gel. PTFE strongly inhibited interleukin 4 (IL-4)-dependent IgE production by lipopolysaccharide-stimulated murine whole spleen cells. In the case of U266 human IgE-bearing B cells, PTFE also showed an inhibitory effect on the IgE production. These results suggest that PTFE has an anti-allergic activity by inhibition of IgE production from B cells. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：283 / 288

页数：6

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